Sertraline teratogenic effects

Published data on pregnant women with more than 2500 exposed outcomes indicate no malformative fetoneonatal toxicity. Increased risk of serotonin syndrome.

Pdf Comments On The Teratogenic Effects Of Sertraline In Mice Cabrera Et Al 2020 Doi 10 1002 Bdr2 1660 from www.researchgate.net

Note Although the listing which follows includes a few adverse reactions which have not been reported with this specific drug the pharmacological similarities among the tricyclic antidepressant drugs require that each of the reactions be considered when Tofranil is administered.

Sertraline teratogenic effects. The serotonergic effects of sertraline may be enhanced when sertraline is combined with tricyclic antidepressants. These results lend further support to a functional role for 5-HT during these stages of development and for the teratogenic potential of 5-HT uptake inhibitors which include a number of clinically relevant antidepressant compounds. Shuey DL et al.

Reproduction studies have been performed in rats and rabbits at doses up to 80 and 40 mgkg respectively giving rise to plasma drug exposure levels similar to or slightly higher than that achieved following the maximum recommended human dose of 200 mg. There was no evidence of teratogenicity at any dose level. However sertraline was associated with delayed ossification.

Animal studies have failed to reveal evidence of teratogenicity. However there was evidence of delayed ossification and effects on reproduction attributed to maternal toxicity. Decreased neonatal survival following maternal administration at exposures similar to or slightly greater than the maximum recommended.

There is limited evidence of teratogenic effects from the use of antidepressants in pregnancy and adverse effects from exposure during breastfeeding. Animal studies have revealed evidence of embryofetal toxicity and effects on postnatal development including teratogenicity at doses greater than human therapeutic doses which were also maternally toxic. There are no controlled data in human pregnancy.

Published data on pregnant women with more than 2500 exposed outcomes indicate no malformative fetoneonatal toxicity. The results of a. Escitalopram sold under the brand names Cipralex and Lexapro among others is an antidepressant of the selective serotonin reuptake inhibitor SSRI class.

Escitalopram is mainly used to treat major depressive disorder or generalized anxiety disorder. It is taken by mouth. Common side effects include trouble sleeping nausea sexual problems and feeling tired.

SSRIs are metabolized by and have effects on the cytochrome P450 system. Fluoxetine paroxetine sertraline citalopram and escitalopram are inhibitors of CYP2D6. Fluoxetine and fluvoxamine are inhibitors of CYP2C19.

Fluvoxamine is an inhibitor of CYP1A2. SSRIs are contraindicated with the concurrent use of MAOIs linezolid and other medications that increase. Drugs that inhibit CYP2D6 such as desipramine paroxetine ritonavir or sertraline and CYP3A4 such as ketoconazole.

Propafenone has been shown to be embryotoxic decreased survival in rabbits and rats when given in oral maternally toxic doses of 150 mgkg day about 3 times the maximum recommended human dose MRHD on a mgm² basis and 600. Note Although the listing which follows includes a few adverse reactions which have not been reported with this specific drug the pharmacological similarities among the tricyclic antidepressant drugs require that each of the reactions be considered when Tofranil is administered. Orthostatic hypotension hypertension tachycardia palpitation myocardial.

Lamotrigine sold as the brand name Lamictal among others is an anticonvulsant medication used to treat epilepsy and to delay or prevent the recurrence of depressive episodes in bipolar disorder. For epilepsy this includes focal seizures tonic-clonic seizures and seizures in Lennox-Gastaut syndrome. In bipolar disorder lamotrigine has not been shown to reliably treat acute depression.

In this study paroxetine was found to demonstrate detrimental effects on delayed verbal recall and paired-associate learning on Day 14 as compared to both sertraline and placebo. 48 Paroxetine levels also were associated with mild behavioral impairment at Day 14. In contrast sertraline plasma levels correlated positively improvement with immediate verbal recall on Day 7 tapping on Day 14.

Oral administration of donepezil to pregnant rats and rabbits during the period of organogenesis did not produce any teratogenic effects at doses up to 16 mgkgday approximately 6 times the maximum recommended human dose MRHD of 23 mgday on a mgm2 basis and 10 mgkgday approximately 7 times the MRHD on a mgm2 basis respectively. Oral administration of donepezil 1 3 10 mgkgday. Sertraline will increase the level or effect of paroxetine by affecting hepatic enzyme CYP2D6 metabolism.

Either increases effects of the other by Mechanism. Avoid or Use Alternate Drug. Both increase serotonin levels.

Increased risk of serotonin syndrome. Paroxetine will increase the level or effect of thioridazine by affecting hepatic. The potential additive effects on heart rate treatment with ozanimod should generally not be initiated in patients who are concurrently treated with QT prolonging drugs with known arrhythmogenic properties.

Haloperidol will increase the level or effect of palbociclib by affecting hepaticintestinal enzyme CYP3A4 metabolism. Experience with oral corticosteroids suggests that rodents are more prone to teratogenic effects from corticosteroid exposure than are humans. When salmeterol was orally administered to pregnant rabbits teratogenicity characteristic of beta-adrenoceptor stimulation was evident at maternal doses approximately 700 times the MRHDID on a mcgm2 basis.

These adverse effects generally occurred at. And be aware of medications that are contraindicated during pregnancy because of teratogenic effects. Be sure to ask all patients about substance abuse.

Be sure to document all other medications that the patient is taking for other medical or psychiatric problems in order to avoid any drug-drug interactions that may interfere with therapeutic efficacy and which may also produce serious side. This drug is classified as a pregnancy Category C drug. There are no adequate and well-controlled studies completed in pregnant women.

Codeine should only be used during pregnancy if the potential benefit outweighs the potential risk of the drug to the fetus Label. Codeine has shown embryolethal and fetotoxic effects in the hamster rat as well as mouse models at about 2-4. In rat studies fetotoxicity and teratogenic effects were observed with acetylsalicylic acid at maternotoxic doses.

Clinical relevance is unknown as the doses used in non-clinical studies are much higher 7 times at least than the maximal recommended doses in targeted cardiovascular indications. Acetylsalicylic acid was extensively investigated with regard to mutagenic and carcinogenic. In reproductive and developmental toxicity studies in rodents and rabbits no teratogenic effects but reduced foetal weight and retarded skeletal ossification were observed at exposure levels below or similar to the expected clinical exposure.

Since higher exposure levels could not be tested in animals due to the severity of maternal toxicity the teratogenic potential of lamotrigine has not. 54 Likes 13 Comments - UCLA VA Physiatry Residency uclava_pmrresidency on Instagram.